920509-32-6 resmetirom

Egenskaper

Utseende gult till orange kristallint fast
Densitet 1,65 ± 0. 1 g/cm3
lagringstemp. Inert atmosfär, förvara i frysen, under -20 examen
Löslighet DMSO: 59. 0 (Max Conc. Mg/ml); 135.56 (Max Conc. MM)
PKA3.96 ± 0. 40
 

Ansökan:

Resmetirom är en selektiv agonist som riktar sig till sköldkörtelhormonreceptor beta (Thr -). Detta läkemedel kan specifikt tas upp av leverceller och reglerar flera metaboliska vägar i levern genom att aktivera Thr -, därmed uppnå flera effekter såsom att minska leverfettansamlingen, främja fettsyrametabolism, minska leverinflammation och reglera kolesterolmetabolism.

 

Synonymer:

Resmetirom

Mgl -3196

920509-32-6

Rezdifffra

2- [3, 5- dikloro -4- [(6- oxo -5- propan -2- yl -1 h-pyridazin {{9} } yl) oxy] fenyl] -3, 5- dioxo -1, 2, 4- triazine -6- karbonitril

Förening 53 [PMID: 24712661]

1,2, 4- triazine -6- karbonitril, 2- (3, 5- dikloro -4- ((1, 6- dihydro {10}} (1- metyletyl) -6- ox o -3- pyridazinyl) oxy) fenyl) -2, 3,4, 5- tetrahydro -3, 5- dioxo-

2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)ox y) fenyl) -3, 5- dioxo -2, 3,4, 5- tetrahydro- (1,2,4) triazin -6- karbonitril

Förening 53 (PMID: 24712661)

1,2, 4- triazine -6- karbonitril, 2- [3, 5- dikloro -4- [[1, 6- diHydro {10}} ({11}} metyletyl) -6- ox o -3- pyridazinyl] oxy] fenyl] -2, 3,4, 5- tetrahydro -3, 5- dioxo-

resmetiromum

Rezdifffra

2-(3,5-dichloro-4-((6-oxo-5-(propan-2-yl)-1,6-dihydropyridazin-3-yl)oxy ) fenyl) -3, 5- dioxo -2, 3,4, 5- tetrahydro -1, 2, 4- triazine -6-} carilitrile

2- (3, 5- dikloro -4- ((6- oxo -5- propan -2- yl -1 h-pyridazin {{9} } yl) oxy) fenyl) -3, 5- dioxo -1, 2, 4- triazine -6- karbonitril

2- (3, 5- dikloro -4- {[{4}} oxo -5- (propan -2- yl) {{7} {6-} } fenyl) -3, 5- dioxo -2, 3,4, 5- tetrahydro -1, 2, 4- triazine -6- Kolitil

2- {3, 5- dikloro -4- [({4}} isOpropyl -6- oxo -1 h-pyridazin -3- Yl) o) o Xy] fenyl} -3, 5- dioxo -4 h -1, 2, 4- triazine -6- karbonitrile

2- (3, 5- dikloro -4- (5- isOpropyl -6- oxo -1, 6- dihyDropyridazin -3-} ph enyl) -3, 5- dioxo -2, 3,4, 5- tetrahydro -1, 2, 4- triazine -6- kolitril

2- (4- (1, 6- Dihydro -5- isopropyl -6- oxopyridazin -3- yloxy) -3, {}}} dichlorop enyl) -2, 3,4, 5- tetrahydro -3, 5- dioxo -1, 2, 4- triazine -6- carcarile

2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydro-pyridazin-3-yloxy ) -phenyl] -3, 5- dioxo -2, 3,4, 5- tetrahydro- [1,2,4] triazine -6- karbonitril

2- [3, 5- dikloro -4- [[1, 6- dihydro -5- ({7}} metyletyl) -6- oxo -3- pyridazinyL] ] fenyl] -2, 3,4, 5- tetrahydro -3, 5- dioxo -1, 2, 4- triazine -6-} carilitrile

 

Populära Taggar: 920509-32-6 Resmetirom, Kina 920509-32-6 Resmetirom -tillverkare, leverantörer, API Small Business API -integration, API -datasekretess, API Startup API -integration, API -datadelning, API -regeringens API -integration, API Healthcare API -integration